The population ageing is a global demographic trend due to declining fertility and increasing longevity. Many countries face major challenges to ensure that their health and social care systems respond to the heterogenous unmet care needs associated with ageing, such as loss of mobility, cognitive decline, malnutrition, depressive mood, visual impairment and hearing loss. Early prevention against the loss of physical and mental capacities (i.e., intrinsic capacity) and ensuring ‘ageing in place’ are critical for promoting the autonomy and the functional ability of older people.

UN Decade of Healthy Ageing (2021-2030) includes an area for action “deliver person-centred integrated care and primary health services responsive to older people”. WHO Integrated Care for Older People (ICOPE) approach promotes a continuum of care that will help to reorient health and social services towards a more person-centred and coordinated model of care that supports optimising intrinsic capacity and functional ability for older people. Transforming health and social systems and service delivery at Macro and Meso levels is required to scale up the ICOPE approach. In this talk, I will talk about the principles of ICOPE approach, experience from different country pilot sites, challenges and enablers to implement ICOPE approach.

– What genes are responsible for the predisposition to accelerated aging
– Biochemical markers of the rate of aging
– Epigenetic markets in the measurement of aging
– Telomeres as markers of biological age
– Functional tests in the practice of an anti-aging specialist

#biological age; #diagnostics; #healthyaging; #healthspam; #lifespam

Although the practice of meditation and mindfulness dates back thousands of years (5000 BC), research into its health benefits is relatively recent.

Scientific evidence proves meditation to counteract the adverse clinical effects of stress in disorders including hypertension, anxiety, insomnia and others. These practice is also associated with reduced expression of genes linked to inflammatory response and stress-related pathways.

There’s still a long way to go as far as scientific research advances on meditation is concerned, but the path is very promising!

KEY WORDS

Meditation – The “antidote” of stress
Health and well being promotion

Free radicals damage biomolecules and are involved in the premature aging process. The endogenous antioxidant system is composed of antioxidant enzymes produced by the body itself to neutralize reactive oxygen species and protect cellular components from their action. Genetic changes in the genes that code for these enzymes have implications for the functioning of this system, making the organism more vulnerable. It is possible, however, to increase the antioxidant pool through exogenous components, which is particularly relevant in the face of a less active endogenous system.

Keywords
free radicals / reactive oxygen species / endogenous antioxidant system / antioxidants / premature aging

In the last decades the frailty syndrome has emerged as a clinical entity of the greatest relevance, becoming one of the most important focuses of attention for geriatricians and other health professionals who provide care to elderly patients.

Frailty is a state of vulnerability due to the loss of biological reserves, which implies an increased risk of complications, even following mild illness or stress.

There is no consensual definition of frailty. Lack of strength is usually the first complaint to arise, followed by weight loss and fatigue, which are central components in all definitions. Sarcopenia and inflammation are components that underlies these symptoms.

To optimize the measures for reversing this pathology, it is essential to identify the respective determinants of the frailty syndrome. These are reduced physical activity, malnutrition, sarcopenia, polymedication, depression, cognitive deficits and lack of social support.

In general, we can consider frailty as a modifiable and reversible multidimensional syndrome, through interventions fundamentally based on a holistic approach, in which physical exercise and healthy eating play an important role.

It is well known that today most of the very elderly die from cardiovascular disease, cancer, dementia and respiratory infections, but for most of the very elderly what limits their ability to live independently until death, is fatigue and lack of strength characteristic of the frailty syndrome.

Keywords:

frailty syndrome; weight loss and fatigue; Sarcopenia; Inflammation; Malnutrition

Population aging is much more than a single changing balance between age groups. The sustainable societies of the future must have a clear strategy to face the challenges of demographic aging as irreversible and universal. All counties and regions are facing an evolution from single to a complex reality. The changing balance is demonstrating the importance of the evolution of the key demographic drivers, the ageing of older population, the decline of «traditional political solutions» and the diversity of old age, the fragmentation of «ancient concepts», the new questions of «healthy ageing» (health care, the importance of engagement, inflammaging…).

Keywords

demographic ageing; healthy aging; stereotypes of older age; the new quantitative vision; a global political age

Although the practice of meditation and mindfulness dates back thousands of years (5000 BC), research into its health benefits is relatively recent.

Scientific evidence proves meditation to counteract the adverse clinical effects of stress in disorders including hypertension, anxiety, insomnia and others. These practice is also associated with reduced expression of genes linked to inflammatory response and stress-related pathways.

There’s still a long way to go as far as scientific research advances on meditation is concerned, but the path is very promising!

KEY WORDS

Meditation – The “antidote” of stress
Health and well being promotion

The right approach to climacteric and menopause with a view to Longevity! Quality of life in a new phase of life! Which hormones are suitable?

#menopause #hormones #wellbeing #antiaging #qualityoflife #healthyaging #inflammaging

Integrative and biological dentistry seeks to identify, neutralize and treat all interfering fields of the oral cavity that may affect systemic health.

We know that inflammation is the basis of all disease and the oral cavity and the balance of its microbiome has a significant impact on controlling inflammation and improving our health. In the mouth, there are many situations that can silently and chronically increase the levels of systemic inflammation and microbiome deregulation, namely the presence of root canals, cavitations in the jaws, dental amalgams, periodontal disease, cavities, etc.

This presentation will aim to alert health professionals and patients in general to the importance of observing the mouth in a comprehensive and integrative way, drawing attention to the situations that we find most frequently and that have a greater impact on health changes.

Keywords

Oral microbiome; oral cavity; silent inflammation; cavitation; root channel

The increasing and global trend that medicinal plants and herbal products are generally safe, following holistic perceptions of disease, is gradually but slowly shaping the management and treatment of several diseases in the so-called Western world. While there is an apparent discredit based on the absence of clinical data on the therapeutic efficacy of some plants, in other cases there is an assumption that this same innocuousness also translates into the absence of toxicity. In fact, these are two diagonally opposed views, and both can be portrayed as being wrong. 

Botanical ingredients based on plants, algae, fungi or lichens, have become widely available on the European Union market offering numerous products that, while leading to beneficial effects and/or having health-promoting properties, also encompass side effects, interactions with conventional drugs, and might not be suitable to specific groups of individuals. Indeed, there is a complex regulatory framework by the European Medicines Agency (EMA) on the quality of herbal medicinal products, but also specific regulations on different categories of botanicals that enable their development as food supplements, cosmetics or as medical devices. 

This presentation will cover the well settled role of natural products on drug development and health care, that will continue to rely on the biosynthetic richness of natural sources. Also, it is worth to recall in mind that the strategic and systematic analysis of ethnomedicinal surveys and reports from empirical clinical practice with medicinal plants, remains a logical starting point for drug discovery and development of herbal products. 

Keywords

Drug Discovery; Ethnopharmacology; Phytochemistry; Phytotherapy; Traditional Medicine

According to the World Health Organization, chronic illness and disease are the leading causes of death worldwide – and they’re on the rise.

Why are we getting sicker? For many of us, it’s due to exposure to mycotoxins – small toxins produced by fungi that are present in our food and homes.

At the “4TH INTERNATIONAL HEALTHY AGING SUMMIT T 2023”, I will present the latest medical and scientific data connecting mycotoxins to illness and how to heal yourself and your loved ones. If you are suffering from brain fog, chronic pain, fatigue, headaches, acute memory loss, insomnia, digestive issues, stress, and food sensitivities are on a long list of symptoms that doctors often misunderstand and misdiagnose. if you’ve been living with any of these chronic symptoms, you might have mycotoxin-related illness mycotoxins are small toxic compounds produced by mold and fungi and they are toxins that can disrupt our immune system and lead to many health conditions involving many different issues they often appear unrelated the World Health Organization names mycotoxins as a health threat to humans, but this is often not recognized by many doctors it’s just not in standard medical training. Therefore it gets misdiagnosed.

We created the Summit to share our experience with you, and it is also an opportunity for us to go deeper with other well-known doctors and healers who are on this path of learning and exploring a better understanding of chronic complex illness. We wish to share this with you The Cutting Edge of Science called Functional Medicine. You’ll discover the dangers of mycotoxin exposure, how to avoid or limit your exposure to mycotoxins, and how to properly detox from mycotoxins when seeking a diagnosis.

If you have a chronic illness or unexplained symptoms (or if you want to support a loved one), you won’t want to miss this event.

Keywords

healthy aging; misdiagnosing; mycotoxins; chronic symptoms; illness

Aging and inflammation contribute crucially to cardiovascular and cerebrovascular diseases, the leading causes of death and disability worldwide. The concept of inflammatory aging recognizes that the low-grade inflammatory pathways observed in the elderly contribute to cv risk. Functional cardiovascular approach promotes lifestyle health and prevent inflammations and, consequently, cardiovascular disease.

#Inflammaging #FunctionalCardiology #CardiovascularDisease #Prevention #ihas #ihas2023 #healthyagingsummit #healthyaging #healthyaginglifestyle

Intermittent fasting has shown benefits in preventing metabolic and autoimmune diseases and healthy aging. Diets that mimic fasting can thus constitute a non-pharmacological tool in the control of diseases, inflammation, and intestinal microbiota. Intermittent fasting or diets that mimic fasting can directly affect intestinal microbial composition, function, and host interaction is highly determinant for overall health.

Main Message

It is possible to stay young and healthy and prevent disease. Intermittent fasting and diets that mimic fasting are a fundamental tool in the control of inflammation and intestinal microbiome, situations highly correlated with premature aging and the emergence of diseases.

Keywords

intermittent fasting; inflammation; microbiome; gut microbiota; healthy aging; young and healthy.

Mitochondria are dynamic organelles whose number, shape and protein composition vary in different metabolic and differentiation states and are involved in a plethora of vital processes in the cell. Tremendous scientific advances in understanding the mechanisms of cellular aging and senescence have been made in recent decades, allowing researchers to link human longevity and health to mitochondrial function. Mitochondrial degeneration has been shown to be the major cause of age-related deterioration and scientific reports concluded that the tissues of a 70-year-old man contained 95% damaged mitochondria compared to almost no damage in that of a 5- year-old child. Hundreds of scientific papers link defective mitochondria to virtually degenerative diseases such as Alzheimer’s, diabetes, cardiovascular disease, obesity and cancer. 

Cell therapy is a regenerative biomedical treatment based on the combination of peptides, amino acids, proteins, growth factors, transcription factors and hormones derived from cellular tissues with the aim of biochemical, metabolic and immunological modulation as well as cellular restoration. Being a fusion of cell therapy and mitochondrial medicine, mitochondrial organelle cell therapy is a range of peptides that broadens the horizons of therapeutic rejuvenation and creates new opportunities for aesthetic and anti-aging practitioners. Mitochondrial peptides contain an immaculate blend of cellular peptides, predominantly specific to mitochondria, extracted to ensure rapid cell regeneration and restoration of normal function. 

The aim of this talk is to present the potential for clinical use of mitochondrial cell peptides in anti-aging and regenerative practice. 

state of the art

Mitochondria are cytosolic organelles that have essential functions as a metabolic center that interconnects several anabolic and catabolic processes, including adenosine triphosphate (ATP) production through oxidative phosphorylation, the tricarboxylic acid (TCA) cycle, β-oxidation of fatty acids, heme synthesis steroidogenesis or apoptosis, iron-sulfur cluster biogenesis, calcium homeostasis, and regulation of cellular redox state. The important metabolic role of mitochondria is reflected in their involvement in multiple signaling pathways in the cell, including calcium signaling and apoptosis. To fulfill these multiple functions, mitochondria comprise a large proteome of approximately 1000 proteins. 

One of the unique features of these organelles is the presence of an extrachromosomal mitochondrial genome (mtDNA), along with all the machinery necessary to replicate and transcribe the mtDNA. Although mitochondria contain an autonomous genome, the vast majority of mitochondrial proteins are encoded in nuclear DNA and translated in the cytoplasm. These precursor proteins are imported into the mitochondria by specialized machinery that decodes structural signals in the precursor amino acid sequence to distribute them appropriately into four mitochondrial compartments: outer membrane (OM), intermembrane space (IMS), inner membrane (IM), and matrix.

Mitochondria harbor a conserved proteolytic system capable of degrading polypeptides to amino acids and, therefore, have been considered a final destination for proteins. Several ATP-dependent proteases ensure quality control of mitochondrial proteins in different subcompartments and regulate the biogenesis of the organelle. The vast majority of peptides detected originate from proteins residing in the inner membrane and matrix space and are released from mitochondria in an ATP-dependent manner. 

The peptides released from the mitochondria are generated after degradation of a large number of matrix-localized proteins. The peptides released, individual peptides or a set of peptides could indicate the functional status of mitochondria in the cell. 

Finally, mitochondria have emerged as critical regulators of innate immune responses to both pathogens and cellular stress. They harbor numerous modulators, which play a direct role in the assembly of innate sensing compounds that trigger the host immune response under sterile and non-sterile conditions. Several lines of evidence indicate the existence of a complex molecular interplay between mechanisms involved in inflammation and metabolism. Mitochondrial function appears to be involved in innate immunity at several stages as diverse as the transcriptional regulation of inflammatory cytokines and chemokines and their maturation by inflammasomes. 

INTEREST OF MITOCHONDRIAL THERAPY IN ANTI-AGING MEDICINE 

In summary, the difference in function between different cells in the body depends not only on the number and shape of cell organelles, but, more importantly, on the peptide signals that signal each organelle to communicate with the other organelles to form a team and act. the function that this cell is supposed to do. The mitochondria receive signals from the nucleus in the form of peptides and multiple chemicals that are subsequently utilized and used by the mitochondria to modulate their activity to produce energy, regulate the cell cycle, stimulate cell proliferation and regeneration, and prevent cell senescence, apoptosis and cell death. 

As aging occurs, the strength and volume of signals to the mitochondria decrease. The mitochondria take this as a command to stop functioning and send signals back to the nucleus to stop cell proliferation and initiate apoptosis and cell death. 

The use of Mitochondrial Cell Therapy peptides in regenerative and anti-aging practice are the main indications: 

– Repair of cell viability: ability to recover optimal cell metabolism;
– Revitalization of organ function;
– Detoxification;
– Inflammatory modulation;
– Hormonal balance. 

In conclusion, mitochondrial cell therapy offers an important tool in clinical anti-aging practice and is a key approach in strengthening the renewal of signals received by mitochondria and their regenerative potential in cellular and tissue rejuvenation. 

Keywords: Healthy Aging; Inflammaging; Mitochondrial cell therapy; anti-aging practice; tissue rejuvenation

Although the practice of meditation and mindfulness dates back thousands of years (5000 BC), research into its health benefits is relatively recent.

Scientific evidence proves meditation to counteract the adverse clinical effects of stress in disorders including hypertension, anxiety, insomnia and others. These practice is also associated with reduced expression of genes linked to inflammatory response and stress-related pathways.

There’s still a long way to go as far as scientific research advances on meditation is concerned, but the path is very promising!

KEY WORDS

Meditation – The “antidote” of stress
Health and well being promotion

Enzymes are very specific biocatalysts, of protein origin, without which human metabolism would be so slow that life would be impossible. About 5,000 enzymes are known to act in the biochemical pathways of the human organism.

Enzymes have a wide application in the field of health and aesthetics, and with their use in various food supplements, we can promote healthy aging (Healthy Aging) and reduce inflammatory processes, which are at the origin of many pathologies, and which tend to increase with age (Inflammaging).

Strategies that can slow cellular aging include changes in diet, intermittent fasting, lifestyle and drugs that modulate intracellular signaling. Exercise is a promising lifestyle intervention that has shown antiaging effects by extending lifespan and healthspan through decreasing the nine hallmarks of aging and age-associated inflammation. Physical exercise preconditioning is based on a phenomenon called “Hormesis”, which is a beneficial adaptation strategy for the survival of organisms in the face of an attack and that goes back to the origins of life.

Many studies have shown that AMPK as a central regulator of the cellular effects of exercise due to its integrative effects in different tissues.

Physical performance, is the most important health marker known in nowdays (exercise and health, 203.462 citations in PubMed). It can be expressed as the Maximum Oxygen Consumption that a person can achieve (VO2 max) or the equivalent in MET’s (one MET is the caloric expenditure necessary to keep the body alive at rest and is equivalent to 3.5 ml / Kg of VO2 consumption). People who can reach 8 MET’s or higher (who have the ability to raise at least 8 times what they burn at rest) have a 100% survival, that is, in theory they cannot die from disease. It has been proven that there is a linear relationship between VO2max or maximum MET’s that a person can reach and mortality; less MET’s, more mortality. The good news is that people who are classified between 2 and 8 MET’s, for each MET they improve with training, increase their survival by 14%.

Clinical preconditioning with physical exercise can be used as a non-pharmacological therapeutic strategy to improve the life expectancy and longevity.

5 keywords as the main subjects/approach;
Aging, mitochondria, physical exercise, longevity

1. Mitochondrial biogenesis – fusion, fission, mitophagy. Aging is complex state, which include obligatory the impairement of mitochondrial biogenesis.
2. How to check and consierge the mitochondrial biogenesis
3. Pharmacology of mitochondrial biogenesis – nicotinamide adenine nucleotide, Ganoderma lucidem and Reishi, alfa lipoic acid, peptides, urolitin A, mitoQ, etc
4. Non pharmacological techniques – HHIT, HIIT, photobiomodulation, cold explosure.

Key words: mitochondrial biogenesis, aging, mitochondria, nutrients, pharmacology, photobiomodulation, HHIT, HIIT, cryotherapy

For more than 2 million years, our metabolic adaptation to seasonal food availability was considered to be a survival advantage. In the course of evolution, our organism has had to choose its fuel and adapt itself and to do this it became flexible. The concept of metabolic flexibility was particularly linked to the capacity of mitochondria to select fuel in response to nutritional changes. Normal energy metabolism is characterized by periodic shifts in glucose and fat oxidation, as the mitochondrial machinery responsible for carbon combustion switches freely between alternative fuels according to physiological and nutritional circumstances. These transitions in fuel choice are orchestrated by an intricate network of metabolic and cell signaling events that enable exquisite crosstalk and cooperation between competing substrates to maintain energy and glucose homeostasis. As such, mitochondria are the final acceptors for metabolic substrates and are the main players for understanding the pull concept of metabolic flexibility.

Metabolic flexibility is the ability of cells to switch from a state of predominant lipid oxidation and high rates of fatty acid uptake, during fasting conditions, to the suppression of lipid oxidation and increased glucose uptake, oxidation, and storage, under insulin-stimulated conditions or after a meal. Unfortunately, humans switched their primal lifestyle towards a plethora of energy-dense foods, persistent psycho-emotional stressors and a dramatic lack of exercise in record time. Metabolic congestion, nutrient overload and heightened substrate competition results in mitochondrial indecision impaired fuel switching, and energy dysregulation. All this favor a decline in metabolic flexibility and this can lead to cardiovascular disease, diabetes, diabesity, cancer and promote unsuccessful aging. In fact, metabolic flexibility is negatively correlated with aging. Several age-related changes, such as hyperinsulinemia, ectopic lipid accumulation, mitochondrial dysfunction, cellular senescence, sedentary lifestyle and muscle mass deterioration, affect metabolic flexibility simultaneously.

Strategies for decongesting mitochondria and improving metabolic flexibility predominantly include lifestyle interventions, such as personalized nutrition and physical training, stress management and precision supplementation.

Flavonoids have been reported to favour cardiovascular protection. Preservation of vascular endothelium integrity and functionality represents an unmet medical need. Indeed, endothelial dysfunction leads to decreased nitric oxide bioavailability and to endothelial activation, teherefore specifically enhancing inflammation and vascular aging. Flavonoids from cocoa and tea as well as from other sources have been associated to improved endotelial function protecting from inlammaging of our arteries.

With aging comes a remodeling of the immune system. Over time, this leads to a decline in immune effectiveness, resulting in increased vulnerability to infectious diseases, decreased vaccination responses, and susceptibility to age-related inflammatory diseases. This phenomenon, called immunosenescence, is multifactorial and affects both natural and acquired immunity. As aging is a plastic process, it is influenced by both nutritional and pharmacological interventions. 

Regenerative biomedicine aims to use cutting-edge technology specialized in cell therapy and tissue-derived peptides; as well as their regenerative factors to combat immunosenescence and rejuvenate the immune system. 

The purpose of this conference is to develop the basic concepts on cell therapy in biomedical clinical practice for immune rejuvenation. 

Keywords:

healthy aging; Inflammaging; Mitochondria; Xenogeneic Cell Therapy; Immune Rejuvenation.

Although the practice of meditation and mindfulness dates back thousands of years (5000 BC), research into its health benefits is relatively recent.

Scientific evidence proves meditation to counteract the adverse clinical effects of stress in disorders including hypertension, anxiety, insomnia and others. These practice is also associated with reduced expression of genes linked to inflammatory response and stress-related pathways.

There’s still a long way to go as far as scientific research advances on meditation is concerned, but the path is very promising!

KEY WORDS

Meditation – The “antidote” of stress
Health and well being promotion